Searchable abstracts of presentations at key conferences in endocrinology

ea0029p341.1 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Cardiac hormones are dual inhibitors of vascular endothelial growth factor and the VEGFR2 receptor

Nguyen J P , Frost C D , Lane M L , Skelton W P , Skelton M , Vesely D L

Introduction: The growth of human tumors depends on the formation of new blood vessels and vascular endothelial growth factor (VEGF) helps control this process via inducing new capillaries to sprout from pre-existing blood vessels. Four cardiac hormones which eliminate up to 80% of human pancreatic cancers and up to 86% of human small-cell lung cancers growing in mice were investigated for their effects on VEGF and the VEGFR2/KDR/Flk-1 receptor. The VEGFR2 receptor is the main...